| AS1892802 is a novel and highly selective Rho kinase (ROCK) inhibitor. AS1892802 potently inhibits human ROCK1 (hROCK1), hROCK2, and rat ROCK2 (rROCK2) with IC50s of 122, 52 and 57 nM, respectively. AS1892802 diminishes the inhibition of CYP isoforms for 3A4, 2D6, 1A2, 2C9, and 2C19 with IC50s of 15, 17, 25, 13, and 19 μM, respectively.[1] AS1892802 inhibits IL-1β–induced PGE2 production in a synovial cell line.[2] Orally administered AS1892802 exhibits potent antinociceptive effect in an adjuvant-induced arthritis (AIA) model (inflammatory arthritis model). Orally administered AS1892802 exhibits potent antinociceptive effect in a monoiodoacetate-induced arthritis (MIA) model (noninflammatory arthritis model), with an ED50 of 0.15 mg/kg (MIA model).[1] |
|
手機站
您當前位置是：產品大全 >> 化工 >>
生物化工
免責聲明：以上所展示的信息由會員自行提供，內容的真實性、準確性和合法性由發布會員負責，www.qy6.com對此不承擔任何責任。如有侵犯您的權益，請來信通知刪除。
聯系信息
